CALL FOR PAPERS Islet Biology Cyclin C stimulates -cell proliferation in rat and human pancreatic -cells
نویسندگان
چکیده
Margarita Jiménez-Palomares,* José Francisco López-Acosta,* Pablo Villa-Pérez, José Luis Moreno-Amador, Jennifer Muñoz-Barrera, Sara Fernández-Luis, Blanca Heras-Pozas, Germán Perdomo, Ernesto Bernal-Mizrachi, and Irene Cózar-Castellano Instituto de Genética y Biología Molecular, Universidad de Valladolid-CSIC, Valladolid, Spain; Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan; Pancreatic Islet Isolation Unit, IDIBELL-Hospital Duran i Reynals, Barcelona, Spain; and Departamento de Química Inorgánica, Orgánica y Bioquímica, Universidad de Castilla La Mancha, Spain
منابع مشابه
Co-Transplantation of VEGF-Expressing Human Embryonic Stem Cell Derived Mesenchymal Stem Cells to Enhance Islet Revascularization in Diabetic Nude Mice
Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revasculari...
متن کاملIn-Vitro Anti-Proliferative and Pro-Apoptotic Properties of Sutureja Khuzestanica on Human Breast Cancer Cell Line (MCF-7) and Its Synergic Effects with Anticancer Drug Vincristine
Satureja khuzestanica Jamzad (Marzeh Khuzestani in Persian) is an endemic plant that iswidely distributed in the southern part of Iran. Despite the number of papers published on thisplant, no one has focused on its anticancer effects. Therefore, the present study was designedto investigate the selective cytotoxic and anti-proliferative properties of satureja khuzestanicatotal extract (SKE). MCF...
متن کاملIn-Vitro Anti-Proliferative and Pro-Apoptotic Properties of Sutureja Khuzestanica on Human Breast Cancer Cell Line (MCF-7) and Its Synergic Effects with Anticancer Drug Vincristine
Satureja khuzestanica Jamzad (Marzeh Khuzestani in Persian) is an endemic plant that iswidely distributed in the southern part of Iran. Despite the number of papers published on thisplant, no one has focused on its anticancer effects. Therefore, the present study was designedto investigate the selective cytotoxic and anti-proliferative properties of satureja khuzestanicatotal extract (SKE). MCF...
متن کاملCyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells.
Activation of pancreatic β-cell proliferation has been proposed as an approach to replace reduced functional β-cell mass in diabetes. Quiescent fibroblasts exit from G0 (quiescence) to G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes. Overexpression of cyclin D1, D2, D3, or cyclin E induces pancreatic β-cell proliferation. We hypothesized that cyclin C overexpression would ind...
متن کاملStimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet beta-cell development, but its effects on adult beta-cell function, survival, and proliferation are not well understood. In the present study, we demonstrated that treatment of primary rat pancreatic islets with a cytomegalovirus promoter-driven recombinant adenovirus containing the Nkx6.1 cDNA (AdCMV-Nkx6.1...
متن کامل